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Scientists Harness Gold Nanoparticles to Fight Infection Without Antibiotics

Posted By: NightSky
Date: Saturday, 13-Jul-2024 08:49:53
www.rumormill.news/243268

There is a reason that gold and silver are called the 'Noble' metals. Because the 'Nobles' have used it for thousands of years to cure, and prevent disease or infections. Also used in ORME-ORMUS form to prolong life, supposedly.

It's the hidden science of Gold and Light waves that they keep hidden from the masses.

~NightSky

~~~~~~~~~~~~~~~

Dual-purpose nanoparticles help image and zap entrenched bacteria in animal study

If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slime, are difficult to dislodge. A new strategy may offer a simple way to break up the muck and destroy the bacteria.

Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current antimicrobials are often incapable of disrupting the polymeric biofilm matrix and reaching the bacteria within. Alternative approaches are needed. Here, we described a complex structure of a dextran-coated gold-in-gold cage nanoparticle that enabled photoacoustic and photothermal properties for biofilm detection and treatment. Activation of these nanoparticles with a near infrared laser could selectively detect and kill biofilm bacteria with precise spatial control and in a short timeframe. We observed a strong biocidal effect against both Streptococcus mutans and Staphylococcus aureus biofilms in mouse models of oral plaque and wound infections, respectively. These effects were over 100 times greater than those seen with chlorhexidine, a conventional antimicrobial agent. Moreover, this approach did not adversely affect surrounding tissues. We concluded that photothermal ablation using theranostic nanoparticles is a rapid, precise, and nontoxic method to detect and treat biofilm-associated infections.

Researchers at the University of Pennsylvania and Stanford University have developed sugar-coated gold nanoparticles that they used to both image and destroy biofilms. In a study published in the Journal of Clinical Investigation, the authors demonstrated the diagnostic and therapeutic potential of the nanoparticles on the teeth and wounded skin of rats and mice, eliminating the biofilms in as little as one minute and outperforming common antimicrobials.

“With this platform, you can bust biofilms without surgically debriding infections, which can be necessary when using antibiotics. Plus, this method could treat patients if they are allergic to antibiotics or are infected by strains that are resistant to medication,” said Luisa Russell, Ph.D., a program director in the Division of Discovery Science & Technology at NIBIB. “The fact that this method is antibiotic-free is a huge strength.”

https://www.nibib.nih.gov/news-events/newsroom/golden-solution-quickly-eliminates-bacterial-infections-no-antibiotics-required




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