Oxid Med Cell Longev. 2018; 2018: 4579140.
Published online 2018 Sep 9. doi: 10.1155/2018/4579140
PMCID: PMC6151216
PMID: 30271527
An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System
Dan Wu,corresponding author 1 Qingxun Hu, 2 and Deqiu Zhucorresponding author 1
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Abstract
Hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as important regulators in the cardiovascular system, although they were historically considered as toxic gases. As gaseous transmitters, H2S and NO share a wide range of physical properties and physiological functions: they penetrate into the membrane freely; they are endogenously produced by special enzymes, they stimulate endothelial cell angiogenesis, they regulate vascular tone, they protect against heart injury, and they regulate target protein activity via posttranslational modification. Growing evidence has determined that these two gases are not independent regulators but have substantial overlapping pathophysiological functions and signaling transduction pathways. H2S and NO not only affect each other's biosynthesis but also produce novel species through chemical interaction. They play a regulatory role in the cardiovascular system involving similar signaling mechanisms or molecular targets. However, the natural precise mechanism of the interactions between H2S and NO remains unclear. In this review, we discuss the current understanding of individual and interactive regulatory functions of H2S and NO in biosynthesis, angiogenesis, vascular one, cardioprotection, and posttranslational modification, indicating the importance of their cross-talk in the cardiovascular system.

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Dear RM Agents and Readers,

I was poisoned with the hydrogen sulfide from well water from 2008 to 2011. I still have a bit left in my system I can see that it caused a thickening in places as well as darkening. I didn't even walk like myself. That returned last year.

This year I began using nitic oxide to clean it up and wow are things changing fast. I'm grateful for this discovery; albeit, at the moment I am exhausted due to the process I suppose. I began taking it twice a day to boost the process. The pills I take in the later part of the day I follow with olive oil on my entire body and then on places that are really heavy with it, I hit with a zinc cream also.

As the darkness leaves, the vibrancy is coming back to the skin.

Booming:):):)... Always something to be thankful for if one but looks.

Many Blessings,
CrystalRiver