By Chessmaster - December 15, 2021

Early in the pandemic it was pretty obvious to a lot of doctors that ivermectin seemingly worked. The issue is that there were no well controlled studies and lack of a solid protocol in clinical management. In places like Central and South America Doctors didn’t have time to do controlled studies; they simply prescribed it to all the patients as a triage to stem the overflowing hospital corridors. For many it seemingly worked because they got the drug early in the disease. When there were calls for a clinical trial, there was no control group that hadn’t already been given ivermectin so it suffered from its own success. There are over 80 clinical trials for ivermectin in just the United States right now, but based on the 3CL protease mechanism of action that is so powerful in treating COVID patients, ivermectin is unlikely to attain approval. But there is a new and improved ivermectin called Tollovid and you can buy it TODAY to have immune support. Unfortunately for ivermectin, the variants emerged and they came with a much higher viral load. This is likely why studies done later in the pandemic didn't confirm the early efficacy that the doctors witnessed.

Targeting the 3CL Protease

Pfizer has proved that blocking the 3CL protease is the best method for an antiviral, with its clinical results far surpassing efforts by Merck and others. What we know is that ivermectin is a weak 3CL protease inhibitor so while it might have worked well in the initial stage of the pandemic, once Alpha and Delta arrived with their much higher viral loads, ivermectin simply couldn’t compete once the virus was established in a person. The reason why is discussed later in the article. It’s also likely that ivermectin was showing really weak efficacy that can only be mined through meta analyses since it's such a weak 3CL protease inhibitor—to the point that its benefits cannot easily be measured. And some of these studies gathered through the meta analysis, particularly those showing high efficacy for ivermectin, were fraudulent or biased.

Ivermectin Doubles as a 3CL Protease Inhibitor

Before COVID-19 hit Ivermectin was viewed as a viral inhibitor. In vitro studies showed benefit against HIV, Dengue, West Nile, Yellow Fever, and the Zika virus. The other mechanism of action was that Ivermectin facilitated the transport of proteins to the nucleus . . .

[SNIP]