So back when the vaccine was just getting started, there was reason to believe it would cause serious neurological problems. I love the graphic. Did they realize what they were saying predicted the problems with the vaccine? Not to mention secondary exposure to shed spike protein?

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December 16, 2020
Research strongly suggests COVID-19 virus enters the brain

A study published in Nature Neuroscience shows how spike protein crosses the blood-brain barrier.

Caption: The S1 protein likely causes the brain to release inflammatory products causing a storm in the brain, researchers said.

More and more evidence is coming out that people with COVID-19 are suffering from cognitive effects, such as brain fog and fatigue.

And researchers are discovering why. The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a study published Dec.16 in Nature Neuroscience, researchers found that the spike protein, often depicted as the red arms of the virus, can cross the blood-brain barrier in mice.

This strongly suggests that SARS-CoV-2, the cause of COVID-19, can enter the brain.

The spike protein, often called the S1 protein, dictates which cells the virus can enter. Usually, the virus does the same thing as its binding protein, said lead author William A. Banks, a professor of medicine at the University of Washington School of Medicine and a Puget Sound Veterans Affairs Healthcare System physician and researcher. Banks said binding proteins like S1 usually by themselves cause damage as they detach from the virus and cause inflammation.

“The S1 protein likely causes the brain to release cytokines and inflammatory products,” he said.

In science circles, the intense inflammation caused by the COVID-19 infection is called a cytokine storm. The immune system, upon seeing the virus and its proteins, overreacts in its attempt to kill the invading virus. The infected person is left with brain fog, fatigue and other cognitive issues.

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https://newsroom.uw.edu/news/research-strongly-suggests-covid-19-virus-enters-brain

Here's a link to the Nature Neuroscience paper they are talking about:

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
https://www.nature.com/articles/s41593-020-00771-8

Here are some other interesting papers for background:

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2
https://www.preprints.org/manuscript/202003.0422/v1

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development
https://www.frontiersin.org/articles/10.3389/fcimb.2020.587269/full