Japanese and Hungarian researchers explore "Cleverin" solution for respiratory viruses

https://benthamopen.com/contents/pdf/TOANTIMJ/TOANTIMJ-2-71.pdf

Taiko Pharmaceutical Co., Ltd, 3-34-14 Uchihonmachi, Suita, Osaka, 564-0032 Japan

Abstract: Influenza is a respiratory tract infection, causing pandemic outbreaks. Spanish flu (A/H1N1), a pandemic oc-curred between 1918 and 1919, tolled patients and fatalities of 500 million and 50 million, respectively. Recently, human infection with highly pathogenic avian influenza A/H5N1 and swine influenza [Pandemic (H1N1) 2009] was reported. Because of the population explosion and busy global aircraft traffics, Pandemic (H1N1) 2009 is rapidly spreading world-wide. In addition, it is seriously concerned that H5N1 influenza pandemic would emerge in the very near future. The pandemic will cause the freeze of social activity and the crisis of business continuity, having a serious impact on the global economy consequently. It is fervently desired that efficient methods of infection control against influenza pandemic be developed.

Chlorine dioxide (ClO2) has a strong antiviral effect, and can disinfect the surface of object and the air in space. In recent study on interaction between ClO2 and protein, ClO2 oxidatively modified tyrosine and tryptophan residues, and the pro-tein was structurally denatured. Since hemagglutinin and neuraminidase of influenza virus A/H1N1 were inactivated by the reaction with ClO2, it is likely that denaturation of the proteins caused inactivation of the virus. A low concentration (0.03 ppm) of ClO2 gas, where people can stay for a long period of time without any harmful effect, prevented the death of mice caused by infection of influenza virus delivered as aerosol. We review current information based on the efficiency of ClO2 solution and gas, and also discuss the application of ClO2 against influenza pandemics outbreak.

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https://www.researchgate.net/publication/340247214_Can_chlorine_dioxide_prevent_the_spreading_of_coronavirus_or_other_viral_infections_Medical_hypotheses

"Aim and structure of the present communication

In this editorial, we propose to consider the possibility of developing and implementing antiviral protocols by applying high purity aqueous chlorine dioxide (ClO2) solutions. The aim of this
proposal is to initiate research that could lead to the introduction of practical and effective antiviral protocols. To this end, we first discuss some important properties of the ClO2 molecule, which make it an advantageous antiviral agent, then some earlier results of ClO2 gas application against viruses will be reviewed. Finally, we hypothesize on methods to control the spread of viral infections using aqueous ClO2 solutions"