October 7, 2023
Opinion

The Overlooked Miracle Drug for Cancer? Why Big Pharma Fears Fenbendazole
At least 12 anti-cancer mechanisms of action. Nine research papers reviewed.

By
Influencers

Image Source: 2020 Aug - Deok-Soo Son et al
This article originally appeared on makismd.substack.com and was republished with permission.

Guest post by Dr. William Makis

Papers and Articles Reviewed:

2023 Jun - Movahedi et al - Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
2023 Apr - Chi-Son Chang et al - Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer
2023 Mar - Semkova et al - Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells
2023 Mar - Haebeen Jung et al - Differential cytotoxic effects of fenbendazole on mouse lymphoma EL-4 cells and spleen cells
2022 Sep - Deokbae Park et al - Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
2022 Jan - Li-wen Ren et al - Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle
2020 Aug - Deok-Soo Son et al - The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
2020 Jun - Yong Han et al - Involvement of reactive oxygen species in the anti-cancer activity of fenbendazole, a benzimidazole anthelmintic (leukemia)
2018 Aug - Dogra et al - Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
2023 Jun - Movahedi et al - Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
Benzimidazole drugs (including Fenbendazole) have widely been used as anti-helminth agents in both human and/or livestock since the 1960s
These drugs have rapidly become more popular than previous medications due to superiority in terms of efficacy, toxicity and application
Benzimidazole drugs are considered as non-toxic anti-helminth agents in humans and livestock. Acute toxicities are rarely reported for these drugs.
Neither chronic adverse effects in dogs and rats treated with very high dosages, nor irritation, carcinogenicity or teratogenicity in treated rats and rabbits have been observed
Two major mechanisms of action:
1. antimitotic activity (inhibition of tubulin polymerization by binding to tubulin sites of rapidly dividing cells (leads to cell cycle arrest)
2. disrupt cell metabolic processes by inducing oxidative stress
Result: induce apoptosis (cell death) of rapidly proliferating parasites and cancer cells!

More at the link:
https://vigilantnews.com/post/the-overlooked-miracle-drug-for-cancer-why-big-pharma-fears-fenbendazole
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Many Blessings,
CrystalRiver