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Ivermectin Is An Antiviral & That's Been Known For Years . . .

Posted By: SpaceCommando
Date: Thursday, 27-Apr-2023 11:14:09
www.rumormill.news/221607

In Response To: CGI's Mike: If ivermectin were antiviral, that property would have been noticed by pet owners, vets, farmers, ranchers, pet store operators and others decades ago (RumorMail)

I only spent a few minutes doing an internet search on this subject and found some information that should clear this up.

First of all, ivermectin has been know to have anti-viral properties for years prior to COVID (probably longer than that). Here's an excerpt from a paper published in 2017:

Published: 15 February 2017

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

The Journal of Antibiotics volume 70, pages495–505 (2017)Cite this article

Abstract

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

Article link: https://www.nature.com/articles/ja201711

Regarding the issue of anti-viral properties of ivermectin in livestock there apparently have not been a lot of studies on that. I did find a paper that talked about it's use as an antiviral in cattle though:

Ivermectin also inhibits the replication of bovine respiratory viruses (BRSV, BPIV-3, BoHV-1, BCoV and BVDV) in vitro

Abstract

Bovine respiratory disease (BRD) complex is an important viral infection that causes huge economic losses in cattle herds worldwide. However, there is no directly effective antiviral drug application against respiratory viral pathogens; generally, the metaphylactic antibacterial drug applications are used for BRD. Ivermectin (IVM) is currently used as a broad-spectrum anti-parasitic agent both for veterinary and human medicine on some occasions. Moreover, since it is identified as an inhibitor for importin α/β-mediated nuclear localization signal (NLS), IVM is also reported to have antiviral potential against several RNA and DNA viruses. Since therapeutic use of IVM in COVID-19 cases has recently been postulated, the potential antiviral activity of IVM against bovine respiratory viruses including BRSV, BPIV-3, BoHV-1, BCoV and BVDV are evaluated in this study. For these purposes, virus titration assay was used to evaluate titers in viral harvest from infected cells treated with non-cytotoxic IVM concentrations (1, 2.5 and 5 μM) and compared to titers from non-treated infected cells. This study indicated that IVM inhibits the replication of BCoV, BVDV, BRSV, BPIV-3 and BoHV-1 in a dose-dependent manner in vitro as well as number of extracellular infectious virions. In addition, it was demonstrated that IVM has no clear effect on the attachment and penetration steps of the replication of the studied viruses. Finally, this study shows for the first time that IVM can inhibit infection of BRD-related viral agents namely BCoV, BPIV-3, BVDV, BRSV and BoHV-1 at the concentrations of 2.5 and 5 μM. Consequently, IVM, which is licensed for antiparasitic indications, also deserves to be evaluated as a broad-spectrum antiviral in BRD cases caused by viral pathogens.

Article link: https://pubmed.ncbi.nlm.nih.gov/33713753/




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