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By Michael Erman and Julie Steenhuysen

Drugmakers including Pfizer, GlaxoSmithKline, Bristol Myers Squibb, AstraZeneca and Sanofi plan to raise prices in the United States on more than 350 unique drugs in early January, according to data analyzed by healthcare research firm 3 Axis Advisors.

The increases are expected to come as the pharmaceutical industry prepares for the Biden Administration's Inflation Reduction Act, which allows the government's Medicare health program to negotiate prices directly for some drugs starting in 2026. The industry is also contending with inflation and supply chain constraints that have led to higher manufacturing costs.

The increases are on list prices, which do not include rebates to pharmacy benefit managers and other discounts.

In 2022, drugmakers raised prices on more than 1,400 drugs according to data published by 46brooklyn, a drug pricing non-profit that is connected to 3 Axis. Those are the most increases since 2015.

Notable increases expected include 9% price hikes on Bristol Myers Squibb's personalized CAR-T cell therapies Abecma and Breyanzi, both of which were already more than $400,000 for the blood cancer treatments.

A company spokesperson said there were several driving factors in increasing the list price of the two CAR-T cell therapies, including the rate of inflation, the value of the therapies, and the personalized nature of the CAR-T manufacturing process.

Increases for Pfizer include a 6% rise on the cost of Xeljanz, a treatment for autoimmune diseases including rheumatoid arthritis and ulcerative colitis, and 7.9% increases on cancer drugs Ibrance and Xalkori.

A Pfizer spokesperson said in an email that the company's average list prices for drugs and vaccines in 2023 are well below overall inflation at approximately 3.6%, noting that the increases are needed to support investments in drug discovery.

Pfizer noted that net prices — those the company actually receives for its drugs — have fallen in the past four years because of higher rebates and discounts paid to insurance companies and pharmacy benefit managers.

AstraZeneca is set to raise prices in the 3% range on blood cancer treatment Calquence, non-small cell lung cancer drug Tagrisso and asthma treatment Fasenra.

"AstraZeneca has always taken a thoughtful approach to pricing, and we continue to do so, considering many factors," said company spokesman Brendan McEvoy.

In addition to significant R&D investments, McEvoy said AstraZeneca considers clinical value, size of patient population, government/payer coverage requirements, patient affordability, competition and other market conditions.

Sanofi plans to raise prices on 14 of its drugs or vaccines.

A Sanofi spokesperson said the drugmaker's 2023 pricing actions are consistent with its approach to responsible pricing, adherence to government policies, and the need to respond to evolving trends in the marketplace.