https://www.dovepress.com/detection-of-tick-borne-infection-in-morgellons-disease-patients-by-se-peer-reviewed-article-CCID?

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques

by serological and molecular techniques

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Authors Middelveen MJ, Du Cruz I, Fesler MC, Stricker RB, Shah JS

Received 19 August 2018

Accepted for publication 3 October 2018

Published 9 November 2018 Volume 2018:11 Pages 561—569

DOI https://doi.org/10.2147/CCID.S184521

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Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

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Marianne J Middelveen,1 Iris Du Cruz,2 Melissa C Fesler,3 Raphael B Stricker,3 Jyotsna S Shah2

1Atkins Veterinary Services, Calgary, AB, Canada; 2IGeneX Laboratories, Palo Alto, CA, USA; 3Union Square Medical Associates, San Francisco, CA, USA

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of Borrelia and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. We sought to explore this association further in a cohort of MD patients.
Patients and methods: Sera from 30 patients with MD were tested for antibody reactivity to antigens from the Borrelia burgdorferi (Bb) group and the relapsing fever Borrelia (RFB) group of spirochetes. Tissue and/or body fluid specimens from these patients were also tested for the presence of Bb and RFB infection using PCR technology. In addition, tissue and body fluid specimens were tested for the presence of Bartonella henselae using PCR, and formalin-fixed skin sections from a subset of patients were tested using fluorescent in situ hybridization (FISH) with B. henselae-specific DNA probes.

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