Hey Hot Coffee (Big Hug),

Were you just in my brain, came here to post this and who was on the same track:) This is a question I posed the other day and found the information a few minutes ago.

I know one of the drugs I have been taking is for Malaria --Quinine and this is what sent me off in the direction for this discovery.

Do note it is just a comparative in mice affected with malaria not Coronavirus-19

Many Blessings,
CrystalRiver

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https://kfor.com/health/coronavirus/drug-used-to-originally-fight-malaria-showing-promise-in-treating-coronavirus-oklahoma-medical-research-foundation-says/

Asian Pac J Trop Biomed. 2012 Apr; 2(4): 311–314.
doi: 10.1016/S2221-1691(12)60030-6

PMCID: PMC3609296
PMID: 23569921
Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis
Esmail Abolghasemi,1 Seyed Hassan Moosa-Kazemi,1,* Maryam Davoudi,1 Ahmad Reisi,2 and Mohammad Taghi Satvat3
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Abstract
Objective
To evaluate the effects of quinine and chloroquine against male mice infected with Plasmodium berghei and their adverse effects on the mice testes.

Methods
In this study, 48 adult male mice, (20–25 g), aged 8 to 12 weeks were divided into four groups. This study was carried out from December 2009 until May 2010 in the School of Public Health, Tehran University of Medical Sciences.

Results
The results showed that 58.33% of mice treated with chloroquine were completely recovered. Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9. There was no orchitis found in this group. The mortality of mice after exposing to quinine on day 5 was 8.3%, whereas from day 10 to day 14 it was 91.7%. We found 75% orchitis occurred in quinine treated group. There was a significant difference between quinine and chloroquine effects on the parasite and also mice testes (P<0.05).

Conclusions
In this study, It can be concluded that male mice have full resistance to the quinine. Quinine does not only make male mice recover completely, but also cause inflammation on mice testicles tissue.

Keywords: Quinine, Chloroquine, Orchitis, Plasmodium berghei
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1. Introduction
Malaria is one of the six major infectious diseases in human communities[1]. Annual mortality was reported to be 1.5 to 2.7 million worldwide and it is one of the four diseases causing deaths of children in Africa[2],[3]. Global strategy on malaria treatment is health management, use of beneficial drugs, vector control and training of health care[4]–[6].

Plasmodium parasites are agents of rodent's malaria[7]. The life cycle is similar to another malaria parasite of mammals[8]. The study on the rodent's malaria can be a good model of human malaria infection. Quinine is an antimalarial drug which is made from Cinchona bark[9]. The mode of action of quinine is similar to chloroquine. For the first time, the effects of quinine on the hexokinase activity of Plasmodium berghei (P. berghei) were reported by Fraser and Kermack in 1957[10].

The first report due to quinine resistance in mice was presented by Thompson et al in 1965[11]. Quinine alone or with other antimalarial medications is used to treat malaria cases especially in pregnant women near delivery[12]. Of course, the presence of Plasmodium falciparum (P. falciparum) has been reported even after treatment with quinine in humans[13]. Although it increases the parasite resistance, it is still regarded as one of the most commonly antimalarial drugs[6],[14]–[17].

There are some reports on the effects of chloroquine on some species of rodents infected by Plasmodium chabaudi, Plasmodium yoelii and P. berghei[18]–[20]. Since chloroquine and quinine are the most common antimalarial drugs, their therapeutic effects and risk of resistance to drugs were studied. In this study, we are aimed to assess the adverse effects of the drugs on testis tissue.

More at the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609296/