I took SAM-e years ago...I could not say I noticed much at all. But I did not have this important information at that time. I started taking it recently and have to say when taking SAM-e with B complex, the result is a lot better. It took me a lot of reading and years in order to find this information, it is not readily available.

Hope this helps!

~Bonnie
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"Others say that the “dark cloud has lifted”, and all the negativity and stress is gone. Things that normally would irritate are just brushed off, and you move on.

One big word of caution: SAM-e needs Vitamins B6 & B12 and folate to work. Or supplementing with SAM-e may be a waste of time and money because without adequate levels of these B-Vitamins it will not provide any benefit.

You’ll notice reference to B-Vitamins several times in this article on SAM-e. It is that important. Use Vitamin B6 & B12 and folate every day that you supplement with SAM-e. Or use a B-Complex formula that contains folate (B9) (avoid folic acid)."

https://nootropicsexpert.com/sam-e/