October 11, 2012
Source:
Monash University
Summary:

For the first time, scientists have visualized an interaction between gluten and T-cells of the immune system, providing insight into how celiac disease, which affects approximately one in 133 people, is triggered.

For the first time, scientists have visualized an interaction between gluten and T-cells of the immune system, providing insight into how celiac disease, which affects approximately 1 in 133 people, is triggered.

Published October 11 in Immunity, the discovery was led by Dr Hugh Reid and Professor Jamie Rossjohn of Monash University, Professor Frits Koning of the University of Leiden and Dr Bob Anderson of biotechnology company ImmusanT Inc, based in the US.

An increasingly diagnosed chronic inflammatory disorder, celiac disease affects the digestive process of the small intestine. When a person with celiac disease consumes gluten, their immune system triggers T-cells to fight the offending proteins, damaging the small intestine and inhibiting the absorption of important nutrients into the body. There are currently no treatments available apart from a diet completely free of gluten.

The researchers used the Australian Synchrotron to visually determine how T-cells of the immune system interact with gluten, a protein found in wheat, rye and barley, which causes celiac disease, The discovery will boost attempts to produce a treatment allowing sufferers to resume a normal diet.

About half the population is genetically susceptible to celiac disease because they carry the immune response genes HLA-DQ2 or HLA-DQ8. At least one in 20 people who carry HLA-DQ2 and about one in 150 who have HLA-DQ8 develop celiac disease, but people with other versions of the HLA-DQ genes are protected.

This has led researchers to question how the immune system senses gluten.

Dr. Reid, a senior research fellow at Monash University, said the discovery was an important breakthrough for celiac disease and autoimmune disease.

"This is the first time that the intricacies of the interaction between gluten and two proteins that initiate immune responses have been visualized at a sub-molecular level," Dr. Reid said.

This insight into a central event in celiac disease will assist ImmusanT