For the last 18 months, I have been discovering just how much genetic polymorphisms(mutations) can and DO affect one's health, both physically and emotionally. It really aggravates a difficult emotional situation, when someone with MTHFR,COMT,CBS,
and other genetic problems, are told that it's all in your head - get your life in order. IT CAN'T be done until the genetic issues are resolved. Many studies indicate that the general population has up to 60% MTHFR variants, let alone all the others that affect
neurotransmitter production and proper function. I think "your life is out of balance" needs to be accessed too, but only after accurate genetic testing. I had enough of "it's all in your head" with Lyme. To add insult to injury, when genetic polymorphisms are the actual causative factor in emotional problems, is enough to send fragile individuals over the edge! If you Google just the MTHFR variant, let alone all the others, and depression/anxiety, you'll get enough links to keep you busy for quite a while!
Lymerick
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MTHFR Gene Mutations and Disease: Understanding the Link
http://thyroid.about.com/od/MTHFR-Gene-Mutations-and-Polymorphisms/fl/The-Link-Between-MTHFR-Gene-Mutations-and-Disease-Including-Thyroid-Health.htm

Homocysteine and Depression in Later Life
http://archpsyc.jamanetwork.com/article.aspx?articleid=482884

Neuropsychiatric & Neurological Conditions: MTHFR mutations have been linked to neuropsychiatric conditions due to the indirect effects of MTHFR activity on the production of serotonin, dopamine and norepinephrine, as well as the potentially toxic effect of hyperhomocysteinemia. Schizophrenia-like syndromes, bipolar disorder, Parkinson’s disease, Alzheimer’s disease and vascular dementia have all been associated with one or more mutations of the MTHFR gene (Lewis, X. Molecular Psychiatry. 2006;11, 352–360).

Insomnia, irritability, forgetfulness, endogenous depression, organic psychosis, peripheral neuropathy, myelopathy and restless leg syndrome are all also mentioned in the literature as potentially being influenced by this enzyme deficiency. The MTHFR C677T homozygous genotype has also been associated with an increased risk for migraine with aura in most ethnic groups except for Caucasian populations (Schurks M., et al. Headache. 2010; 50(4):588-99).
In a recent metanalysis, there was a relationship between the C677T mutation and increased susceptibility for depression (Lewis, X. Molecular Psychiatry. 2006;11, 352–360).
http://www.holisticprimarycare.net/topics/topics-a-g/functional-medicine/1353-mthfr-mutation-a-missing-piece-in-the-chronic-disease-puzzle