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NAC (N-ACETYLCYSTEINE) for Pain and Inflammation and in Type-2 Diabetes

Posted By: hobie
Date: Wednesday, 13-Jan-2021 05:52:26
www.rumormill.news/116596

In Response To: 43 BENEFITS OF NAC (N-ACETYLCYSTEINE) (CrystalRiver)

(Thanks, CR. :)

Just highlighting thee two items from the article you linked to:

=====

1) Pain and Inflammation

NAC is anti-inflammatory. In cells, it could target the same pathway as common anti-inflammatory painkillers (COX-2) [R].

NAC could alleviate complex pain in a study of 146 people over 2 years (DB-RCT), especially in those with poor circulation. The participants took 1,200 mg NAC daily [R].

NAC reduced neuropathic pain in rats by blocking an important inflammatory pathway (matrix metalloproteinases) [R].

NAC (1,200 mg/day) reduced inflammatory markers such as CRP and IL-6 in a study of 24 people with kidney disease. Given to 15 patients with severe burns, NAC reduced oxidative damage, increased antioxidant protection, and reduced inflammatory markers [R, R].

But it had no effect on kidney inflammation in kids nor on leg cramps (RCT) [R, R].

2) Insulin Resistance and Type 2 Diabetes

NAC can target insulin resistance thanks to its capacity to restore antioxidant levels and reduce oxidative stress. Plus, people with type 2 diabetes may have lower glutathione levels that NAC can replenish [R].

In one study, 14 people with type 2 diabetes took 1,200 mg of NAC every day for a week and had their blood drawn shortly after (RCT). NAC increases glutathione in platelets and normalized their activity, which could protect from heart disease in type 2 diabetes [R].

When glutathione is added to white blood cells of people with type 2 diabetes, it restores their immune and bacteria-fighting function. Since NAC increases glutathione throughout the body, it

may be helpful for restoring antioxidant balance in people with diabetes [R].

When given to 128 people before a high-fat meal, NAC could help maintain antioxidants and blood vessel health. It reversed oxidative stress, which was very noticeable in people with type 2 diabetes and insulin resistance. Since the group was medication-naive, NAC may delay or prevent the need for anti-diabetes drugs in type 2 diabetes [R].

Animal studies speak to its benefits too. NAC prevented mice fed a high-fat diet from gaining excessive weight and symptoms of insulin resistance [R].

NAC does not affect type 1 diabetes, though, as factors aside from oxidative stress play a large role [R].

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Articles In This Thread

43 BENEFITS OF NAC (N-ACETYLCYSTEINE)
CrystalRiver -- Wednesday, 13-Jan-2021 05:52:26
NAC (N-ACETYLCYSTEINE) for Pain and Inflammation and in Type-2 Diabetes
hobie -- Wednesday, 13-Jan-2021 05:52:26
Thanks Hobie:) *NM*
CrystalRiver -- Wednesday, 13-Jan-2021 05:52:26

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AN EXPLANATION OF THE FACTIONS