The United Kingdom's decision to leave the European Union is the second major blow to President Barack Obama — and his legacy — in as many days.

The country's historic referendum decision, which brought the resignation — effective in October — of U.K. Prime Minister David Cameron was made official one day after the Supreme Court left Obama's immigration executive order frozen in perpetuity.

On Thursday, Obama pinned much of the blame for the high court's 4-4 split decision on Senate Republicans' unwillingness to confirm his Supreme Court nominee, Judge Merrick Garland, and on House Republicans for blocking a Senate-passed bipartisan immigration overhaul bill in 2013.

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But he cannot blame them for the British EU exit, known as "Brexit."

During a visit to London in April, Obama did not mince words about his opposition to an EU exit. Speaking beside Cameron, the president delivered a forceful case that Britain as an EU member is stronger on the continent and across the globe.

“The United Kingdom is at its best when it is helping to lead a strong Europe. It leverages U.K. power to be part of the European Union,” Obama said, seeming to directly address British voters.
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