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Washington (CNN)Donald Trump escalated his feud with Ted Cruz on Twitter Tuesday — but this time he also involved the Texas senator's wife, who hit back on Wednesday at an impromptu press conference.
The real estate mogul tweeted that the Texas senator should "be careful" or he would "spill the beans on your wife" Heidi Cruz.

"Lyin' Ted Cruz just used a picture of Melania from a G.Q. shoot in his ad. Be careful, Lyin' Ted, or I will spill the beans on your wife!," he tweeted Tuesday evening, just minutes before polls closed in Arizona. Trump tweeted and deleted a similar version of the Tweet about 10 minutes earlier.

Lyin' Ted Cruz just used a picture of Melania from a G.Q. shoot in his ad. Be careful, Lyin' Ted, or I will spill the beans on your wife!

— Donald J. Trump (@realDonaldTrump) March 23, 2016

Trump appears to be referring to a Facebook advertisement targeted to Mormons that shows Trump's wife, Melania, posing nude. That ad was produced by an anti-Trump super PAC, Make America Awesome, which has no known connection to the Cruz campaign.

Cruz responded on Twitter by saying that the ad was not from him and if he went after his wife, then Trump is a "coward."
"Pic of your wife not from us. Donald, if you try to attack Heidi, you're more of a coward than I thought. #classless," Cruz tweeted.

Pic of your wife not from us. Donald, if you try to attack Heidi, you're more of a coward than I thought. #classless https://t.co/0QpKSnjgnE

— Ted Cruz (@tedcruz) March 23, 2016

Heidi Cruz is a senior executive for Goldman Sachs, and took a leave from work in order to help her husband's campaign. She has become one of the campaign's most accomplished fundraisers.
The senator's wife hit back at Trump on the campaign trail in Wisconsin.
Heidi Cruz dishes on 'who Ted is'
"Well, as you probably know by now, most of the things, many of the things others say are not based in reality," Heidi Cruz said.
"I have one job on this campaign, and it is to be helping Ted win this race. And it is, I think, the easiest job in the world, and that is to speak the truth: what I know about my husband, our family, myself," she added.
Heidi Cruz also denied the photo of Melania Trump came from the Cruz campaign.
"In no shape or form are we related to it," she said.
Trump again accused the Cruz campaign of being behind the ad on Wednesday, tweeting, "Lyin' Ted Cruz denied that he had anything to do with the G.Q. model photo post of Melania. That's why we call him Lyin' Ted!"

Lyin' Ted Cruz denied that he had anything to do with the G.Q. model photo post of Melania. That's why we call him Lyin' Ted!

— Donald J. Trump (@realDonaldTrump) March 23, 2016

The Trump campaign did not immediately respond to a request for comment.

Trump previously has used Twitter to threaten the Ricketts family, which has financed a negative ad campaign against him.