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PATENT FOR AERIAL SPRAY VACCINE--CHEMTRAILS?

Posted By: ANON
Date: Saturday, 11-Mar-2000 15:22:13

(21 of 51)

United States Patent 51695,770

Raychaudhuri, et al.

December 9, 1997

Induction of cytotoxic T-lymphocyte responses

Abstract

Methods and compositions useful for inducing a cytotoxic. T lymphocyte response (M) in a human or domesticated or agriculturally important animal.

The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil.

This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished.

This formulation is provided as a stable oil-in-water emulsion.

Inventors: Raychaudhuri; Syamal (San Diego, CA);

Rastetter; William H. (Rancho Santa Fe, CA)

Black; Amelia (Cardiff, CA) Assignee: IDEC Pharmaceuticals Corporation (San Diego, CA)

Appl. No, - 472311 Filed:Jun 7, 1995

U.S. class.. 424/278.1; 424/184.1; 424/204.1; 424/277. 1; 424/283.1

Intern'l Class: A61K 045/05; A61K 039/00; A61K 047/00; A61K

039/39

Field of Search: 424/204. 1, 278.1,277.1,283.1,400,184.1

References Cited [Referenced by)

4770874 U.S. Patent Documents

Sep., 1988

Allison et al. 424/88. 0451216 B1 Foreign Patent Documents

Oct, 1991 Ep.

0682040 A1 Nov, 1995 Ep.

Other

References

Brugh et al 1983 Am J Vet Res 44 (1) pp. 72-75, Jan. 1, 1983.

Mackewicz et al 1991 J Clin Invest 87 pp. 1462-1466, Apr. 1991.

Nicholas et al 19?1 Virology 182 pp, 664-671, Jan. 1, 1991.

Rouse et al. 1988, Reviews 6f Inf. Dis. 10 (1) pp. 16-33, Jan. 1, 1988.

Primary Examiner,

Woodward; michael P.

Assistant examiner Zeman; Mary K.

Attorney, Agent or Firm: Burns, Doane, Swecker & Mathis, LLP

Parent Case Text

This application is a continuation-in-part of pending U.S. Ser. No. 08/351,001 filed Dec. 7, 1994

which is a continuation-in-part of pending U.S. Ser. No, 07/919,787 filed Jul. 24, 1992 U.S. Pat, No. 5,585,103

which is a continuation-in-part of U.S. Ser. No. 07/735,069, filed Jul. 25, 1991, entitled "Induction of Cytotoxic T-Lyrnphocyte Responses," by Syamal Raychaudhuri and William H, Rastetter (now abandoned).

All of these applications are incorporated by reference in their entirety. This invention relates to methods and compositions useful for inducing cytotoxic T-cell mediated responses in humans, and domesticated or agricultural animals.

1. A composition comprising , g a papillomavirus anitigen mixed with a microfluidized antigen formulation comprising:

(a) a stabilizing detergent,

(b) a micelie-forming agent, and

(c) a biodegradable and biocompatible oil,

said antigen formulation being formulated as a stable oil-in-water emulsion,

said antigen formulation being substantially free of immunostimulating peptides and wherein

said composition upon administration to an Animal selected from the group consisting of humans, domesticated animals and agricultural animals is capable of inducing a specific cytotoxic T-lymphocyte response against the papillomavirus antigen contained in the composition.

2. The composition of claim 1, wherein said papillomavirus antigen is selected from the group consisting of HPV16 E6 antigen, HPV16 E7 antigen, HPV18 E6 antigen, HPV18 E7 antigen, HPV6 E4 antigen, HPV6 L I antigen, HPV 11 E4 antigen and HPV 11L 1 antigen.

3. A method for treating cervical cancer comprising administering a therapeutically effective

(no further pages were provided)

*********************

DO ANY RMNEWS AGENTS HAVE ADDITIONAL OR SUPPORTING INFORMATION FOR THIS?

COULD THIS BE THE PATENT FOR WHATEVER IS BEING SPRAYED ON US BY THE CHEMTRAILS?


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AN EXPLANATION OF THE FACTIONS